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The Great Terror: A Reassessment

October 27, 2010 by biotechcheck.com · 5 Comments 

The Great Terror: A Reassessment

The definitive work on Stalin’s purges, Robert Conquest’s The Great Terror was universally acclaimed when it first appeared in 1968. Edmund Wilson hailed it as “the only scrupulous, non-partisan, and adequate book on the subject.” George F. Kennan, writing in The New York Times Book Review, noted that “one comes away filled with a sense of the relevance and immediacy of old questions.” And Harrison Salisbury called it “brilliant…not only an odyssey of madness, tragedy, and sadism, but a work of scholarship and literary craftsmanship.” And in recent years it has received equally high praise in the Soviet Union, where it is now considered the authority on the period, and has been serialized in Neva, one of their leading periodicals.

Of course, when Conquest wrote the original volume two decades ago, he relied heavily on unofficial sources. Now, with the advent of glasnost, an avalanche of new material is available, and Conquest has mined this enormous cache to write a substantially new edition of his classic work. It is remarkable how many of Conquest’s most disturbing conclusions have born up under the light of fresh evidence. But Conquest has added enormously to the detail, including hitherto secret information on the three great “Moscow Trials,” on the fate of the executed generals, on the methods of obtaining confessions, on the purge of writers and other members of the intelligentsia, on life in the labor camps, and many other key matters.

Both a leading Sovietologist and a highly respected poet, Conquest here blends profound research with evocative prose, providing not only an authoritative account of Stalin’s purges, but also a compelling and eloquent chronicle of one of this century’s most tragic events. A timely revision of a book long out of print, this updated version of Conquest’s classic work will interest both readers of the earlier volume and an entirely new generation of readers for whom it has not been readily available.

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Experimental Researches in Electricity, Volume 1

October 27, 2010 by biotechcheck.com · 1 Comment 

Experimental Researches in Electricity, Volume 1

I have been induced by various circumstances to collect in One Volume the Fourteen Series of Experimental Researches in Electricity, which have appeared in the Philosophical Transactions during the last seven years: the chief reason has been the desire to supply at a moderate price the whole of these papers, with an Index, to those who may desire to have them.

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Genome: The Autobiography of a Species in 23 Chapters (P.S.) Reviews

August 18, 2010 by biotechcheck.com · 5 Comments 

Genome: The Autobiography of a Species in 23 Chapters (P.S.)

The genome’s been mapped.
But what does it mean?

Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.

Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington’s disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

Science writer Matt Ridley has found a way to tell someone else’s story without being accused of plagiarism. Genome: The Autobiography of a Species in 23 Chapters delves deep within your body (and, to be fair, Ridley’s too) looking for dirt dug up by the Human Genome Project. Each chapter pries one gene out of its chromosome and focuses on its role in our development and adult life, but also goes further, exploring the implications of genetic research and our quickly changing social attitudes toward this information. Genome shies away from the “tedious biochemical middle managers” that only a nerd could love and instead goes for the A-material: genes associated with cancer, intelligence, sex (of course), and more.

Readers unfamiliar with the jargon of genetic research needn’t fear; Ridley provides a quick, clear guide to the few words and concepts he must use to translate hard science into English. His writing is informal, relaxed, and playful, guiding the reader so effortlessly through our 23 chromosomes that by the end we wish we had more. He believes that the Human Genome Project will be as world-changing as the splitting of the atom; if so, he is helping us prepare for exciting times–the hope of a cure for cancer contrasts starkly with the horrors of newly empowered eugenicists. Anyone interested in the future of the body should get a head start with the clever, engrossing Genome. –Rob Lightner

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Metabolomics: Methods and Protocols (Methods in Molecular Biology) Reviews

June 30, 2010 by biotechcheck.com · Leave a Comment 

Metabolomics: Methods and Protocols (Methods in Molecular Biology)

Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies. Part I of this volume focuses on GC-MS techniques; specifically, attention is given to metabolite profiling in blood plasma, construction and application of mass spectral and retention time index libraries, and metabolomic profiling of natural volatiles. In Part II, emphasis shifts to data integration and data mining techniques, and specific protocols discuss improving pattern recognition and biomarker selection for systems level approaches, and visualization and analysis of molecular and metabolomic data. Parts III, IV, and V examine the coupling of capillary electrophoresis and mass spectrometry, classical reversed phase liquid chromatography-mass spectrometry, and electrochemical detection of metabolites using HPLC separations coupled with coulometric electrode array detectors. In Part VI, protocols for the determination of metabolic flux rates are presented and a theoretical framework for metabolic pathway network analysis is provided. The volume concludes with an examination of cutting-edge NMR protocols.

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